A low complexity approximation of probabilistic appearance models

Appearance models yield a compact representation of shape, pose and illumination variations. The probabilistic appearance model, proposed by Moghaddam et al. (Moghaddam and Pentland, 1997; Tipping and Bishop, 1997b), has recently shown excellent performances in pattern detection and recognition, outperforming most other linear and non-linear approaches. Unfortunately, the complexity of this model remains high. In this paper, we introduce an efficient approximation of this model, which enables fast implementations in statistical estimation-based schemes. Gains in complexity and cpu time of more than 10 have been obtained, without any loss in the quality of the results.Les modèles d'apparence permettent d'encoder les variabilités de forme, de pose, et d'illumination dans une seule représentation compacte. Le modèle d'apparence probabiliste de Moghaddam et al. (Moghaddam and Pentland, 1997; Tipping and Bishop, 1997b), reposant sur une interprétation statistique de l'Analyse en Composantes Principales (ACP) s'est récemment illustré par ses excellentes performances en détection et en reconnaissance des formes, surpassant de nombreuses autres méthodes linéaires et non linéaires. Ce modèle, performant, se heurte toutefois à une complexité calculatoire importante. Nous proposons, dans cet article, une approximation de ce modèle qui se prête à une mise en oeuvre rapide, dans le cadre de schémas d'estimation statistique. Des gains en complexité et en temps de calcul supérieurs à 10, sont obtenus, sans aucune perte de qualité dans les résultats des traitements

Large-scale variations of the dust optical properties in the Galaxy

We present an analysis of the dust optical properties at large scale, for the whole galactic anticenter hemisphere. We used the 2MASS Extended Source Catalog to obtain the total reddening on each galaxy line of sight and we compared this value to the IRAS 100 microns surface brightness converted to extinction by Schlegel et al (1998). We performed a careful examination and correction of the possible systematic effects resulting from foreground star contamination, redshift contribution and galaxy selection bias. We also evaluated the contribution of dust temperature variations and interstellar clumpiness to our method. The correlation of the near-infrared extinction to the far-infrared optical depth shows a discrepancy for visual extinction greater than 1 mag with a ratio A_V(FIR) / A_V(gal) = 1.31 +- 0.06. We attribute this result to the presence of fluffy/composite grains characterized by an enhanced far--infrared emissivity. Our analysis, applied to half of the sky, provides new insights on the dust grains nature suggesting fluffy grains are found not only in some very specific regions but in all directions for which the visual extinction reaches about 1 mag.Comment: 10 pages, 11 figures, accepted for publication in A&

Far-infrared dust opacity and visible extinction in the Polaris Flare

We present an extinction map of the Polaris molecular cirrus cloud derived from star counts and compare it with the Schlegel et al. (1998) extinction map derived from the far--infrared dust opacity. We find that, within the Polaris cloud, the Schlegel et al. Av values are a factor 2 to 3 higher than the star count values. We propose that this discrepancy results from a difference in $\tau_{FIR}/ A_V$ between the diffuse atomic medium and the Polaris cloud. We use the difference in spectral energy distribution, warm for the diffuse atomic medium, cold for the Polaris cloud, to separate their respective contribution to the line of sight integrated infrared emission and find that the $\tau_{FIR}/ A_V$ of cold dust in Polaris is on average 4 times higher than the Schlegel et al. value for dust in atomic cirrus. This change in dust property could be interpreted by a growth of fluffy particles within low opacity molecular cirrus clouds such as Polaris. Our work suggests that variations in dust emissivity must be taken into account to estimate Av from dust emission wherever cold infrared emission is present (i.e. molecular clouds).Comment: 9 pages, 7 figures, accepted in A&

Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis

Testing for hepatitis C virus (HCV) infection may reduce the risk of liver-related morbidity, by facilitating earlier access to treatment and care. This review investigated the effectiveness of targeted testing interventions on HCV case detection, treatment uptake, and prevention of liver-related morbidity. A literature search identified studies published up to 2013 that compared a targeted HCV testing intervention (targeting individuals or groups at increased risk of HCV) with no targeted intervention, and results were synthesised using meta-analysis. Exposure to a targeted testing intervention, compared to no targeted intervention, was associated with increased cases detected [number of studies (n) = 14; pooled relative risk (RR) 1.7, 95 % CI 1.3, 2.2] and patients commencing therapy (n = 4; RR 3.3, 95 % CI 1.1, 10.0). Practitioner-based interventions increased test uptake and cases detected (n = 12; RR 3.5, 95 % CI 2.5, 4.8; and n = 10; RR 2.2, 95 % CI 1.4, 3.5, respectively), whereas media/information-based interventions were less effective (n = 4; RR 1.5, 95 % CI 0.7, 3.0; and n = 4; RR 1.3, 95 % CI 1.0, 1.6, respectively). This meta-analysis provides for the first time a quantitative assessment of targeted HCV testing interventions, demonstrating that these strategies were effective in diagnosing cases and increasing treatment uptake. Strategies involving practitioner-based interventions yielded the most favourable outcomes. It is recommended that testing should be targeted at and offered to individuals who are part of a population with high HCV prevalence, or who have a history of HCV risk behaviour

Percutaneous Exposure Incidents of the Health Care Personnel in a Newly Founded Tertiary Hospital: A Prospective Study

BACKGROUND: Percutaneous exposure incidents (PEIs) and blood splashes on the skin of health care workers are a major concern, since they expose susceptible employees to the risk of infectious diseases. We undertook this study in order to estimate the overall incidence of such injuries in a newly founded tertiary hospital, and to evaluate possible changes in their incidence over time. METHODOLOGY/PRINCIPAL FINDINGS: We prospectively studied the PEIs and blood splashes on the skin of employees in a newly founded (October 2000) tertiary hospital in Athens, Greece, while a vaccination program against hepatitis B virus, as well as educational activities for avoidance of injuries, were taking place. The study period ranged from October 1, 2002 to February 28, 2005. Serologic studies for hepatitis B (HBV) and C virus (HCV) as well as human immunodeficiency virus (HIV) were performed in all injured employees and the source patients, when known. High-titer immunoglobulin (250 IU anti-HBs intramuscularly) and HBV vaccination were given to non-vaccinated or previously vaccinated but serologically non-responders after exposure. Statistical analysis of the data was performed using Mc Nemar's and Fisher's tests. 60 needlestick, 11 sharp injuries, and two splashes leading to exposure of the skin or mucosa to blood were reported during the study period in 71 nurses and two members of the cleaning staff. The overall incidence (percutaneous injuries and splashes) per 100 full-time employment-years (100 FTEYs) for high-risk personnel (nursing, medical, and cleaning staff) was 3.48, whereas the incidence of percutaneous injuries (needlestick and sharp injuries) alone per 100 FTEYs was 3.38. A higher incidence of injuries was noted during the first than in the second half of the study period (4.67 versus 2.29 per 100 FTEYs, p = 0.005). No source patient was found positive for HCV or HIV. The use of high-titer immunoglobulin after adjustment for the incidence of injuries was higher in the first than in the second half of the study period, although the difference was not statistically significant [9/49 (18.37%) vs 1/24 (4.17%), p = 0.15]. CONCLUSIONS/SIGNIFICANCE: Our data show that nurses are the healthcare worker group that reports most of PEIs. Doctors did not report such injuries during the study period in our setting. However, the possibility of even relatively frequent PEIs in doctors cannot be excluded. This is due to underreporting of such events that has been previously described for physicians and surgeons. A decrease of the incidence of PEIs occurred during the operation of this newly founded hospital

Extinction with 2MASS: star counts and reddening toward the North America and the Pelican Nebulae

We propose a general method for mapping the extinction in dense molecular clouds using 2MASS near-infrared data. The technique is based on the simultaneous utilization of star counts and colors. These two techniques provide independent estimations of the extinction and each method reacts differently to foreground star contamination and to star clustering. We take advantage of both methods to build a large scale extinction map (2.5 x 2.5 degrees) of the North America-Pelican nebulae complex. With Ks star counts and H-Ks color analysis the visual extinction is mapped up to 35 mag. Regions with visual extinction greater than 20 mag account for less than 3% of the total mass of the cloud. Color is generally a better estimator for the extinction than star counts. Nine star clusters are identified in the area, seven of which were previously unknown.Comment: 33 pages, 14 figures, accepted in A

Microbial Dysbiosis in Colorectal Cancer (CRC) Patients

The composition of the human intestinal microbiota is linked to health status. The aim was to analyze the microbiota of normal and colon cancer patients in order to establish cancer-related dysbiosis

Mutation Rate Switch inside Eurasian Mitochondrial Haplogroups: Impact of Selection and Consequences for Dating Settlement in Europe

R-lineage mitochondrial DNA represents over 90% of the European population and is significantly present all around the planet (North Africa, Asia, Oceania, and America). This lineage played a major role in migration “out of Africa” and colonization in Europe. In order to determine an accurate dating of the R lineage and its sublineages, we analyzed 1173 individuals and complete mtDNA sequences from Mitomap. This analysis revealed a new coalescence age for R at 54.500 years, as well as several limitations of standard dating methods, likely to lead to false interpretations. These findings highlight the association of a striking under-accumulation of synonymous mutations, an over-accumulation of non-synonymous mutations, and the phenotypic effect on haplogroup J. Consequently, haplogroup J is apparently not a Neolithic group but an older haplogroup (Paleolithic) that was subjected to an underestimated selective force. These findings also indicated an under-accumulation of synonymous and non-synonymous mutations localized on coding and non-coding (HVS1) sequences for haplogroup R0, which contains the major haplogroups H and V. These new dates are likely to impact the present colonization model for Europe and confirm the late glacial resettlement scenario